Brandon Miller was born in Gardner, Kansas. After performing vocals and guitars with several local cover bands, Miller formed the Brandon Miller Band to record and promote his solo projects: "Slow Train" and "Brandon Miller Band – Live at Knuckleheads". He then joined with the Danielle Nicole Band, singing and playing on both her albums "Live at The Gospel Lounge" and her Concord Records Release, “Cry No More”. Miller toured in support of "Cry No More" internationally at venues such as the Fourth Annual Utah Blues Festival June 2018, the International Blues Festival in Canada in July 2018, the Chenago Blues Festival in 2019 and in Lake Tahoe, Nevada."Cry No More" was nominated for a Grammy Award, would receive the Independent Blues Award for best contemporary CD in Blues Blast Magazine in 2018 and in 2019 garnished three additional Independent Blues Awards. His Live at Knuckleheads Release garnished a nomination for Best Independent Blues Live CD 2019.

Miller performed with many other blues artists such as Monster Mike Welch and Mike Ledbetter and participated in the tribute and fundraiser to Ledbetter after his death. The Brandon Miller Band between 2017 and 2019 opened for blues artist Walter Trout at both Knuckleheads, where Eric Gales was also on the bill, and in Omaha, Nebraska, among other venues.

Virtue And Vice, since its release in 2020, has been reviewed by both in Blues Blast Magazine and Blues Rock Review, where the release was considered for an award as a top blues album of 2020.